| Bioactivity | [Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1]. |
| Target | T cell receptor(TCR). |
| CAS | 188859-65-6 |
| Sequence | His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe |
| Shortening | HSLGKLLGRPDKF |
| Formula | C67H110N20O17 |
| Molar Mass | 1467.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9279-84. |
[Leu144,Arg147]-PLP (139-151)
CAS: 188859-65-6 F: C67H110N20O17 W: 1467.71
-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at po
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.